NLM 1988 Sep-Oct; 3 (5):387–417. Tell your doctor if any of these symptoms are severe or do not go away: restlessness; nausea; vomiting; weakness; headache; Some side effects can be serious. Shorter duration of use was associated with greater increases in SBP and DBP. Drug-Induced Hypertension: Focus on Mechanisms and Management. Hypertension. Within 14 days of MAO inhibitor therapy . Horak F, Zieglmayer P, Zieglmayer R, et al. Pseudoephedrine hydrochloride is less suitable for prescribing. Twenty-four trials had extractable vital sign information (45 treatment arms; 1285 patients). Epub 2005 Nov 29. 2018 Feb;8(2):108-352. doi: 10.1002/alr.22073. In 2004, the Bayer laboratories , in a multicenter prospective randomized double-blind trial against placebo including 643 patients with common cold, found reduction of nasal congestion without side-effects 6 hours after oral intake of pseudoephedrine (30 or 60 mg) associated either to acetylsalicylic acid (1 g) or to paracetamol (500 mg or 1 g). The effect in patients with controlled hypertension demonstrated an SBP increase of similar magnitude (1.20 mm Hg; 95% CI, 0.56 to 1.84 mm Hg). NIH Pseudoephedrine usually starts to work in 15 to 30 minutes; Common side effects include feeling sick, headaches, a dry mouth, a fast or irregular heartbeat, or increased blood pressure. Applies to pseudoephedrine: oral capsule liquid filled, oral liquid, oral solution, oral syrup, oral tablet, oral tablet extended releaseAlong with its needed effects, pseudoephedrine may cause some unwanted effects. 2009;102(2):116-120. doi: 10.1016/S1081-1206(10)60240-2. CNS stimulation, excitability, restlessness . Curr Infect Dis Rep. 2001 Jun;3(3):209-216. doi: 10.1007/s11908-001-0022-7. Pseudoephedrine is also called by … Description: Triprolidine, an alkylamine derivative, is a potent competitive histamine H 1 receptor antagonist blocking the action of histamine to combine with its receptor sites and exert its usual effects in target cells. Higher doses and immediate-release preparations were associated with greater BP increases. When used for self-medication, see health-care provider if symptoms … Pseudoephedrine hydrochloride is less suitable for prescribing. The effects of pseudoephedrine may be increased by doxapram and oxytocin (as there is a risk of hypertension) and its absorption may be increased by aluminium hydroxide. Pseudoephedrine usually starts to work in 15 to 30 minutes; Common side effects include feeling sick, headaches, a dry mouth, a fast or irregular heartbeat, or increased blood pressure.  |  Pseudoephedrine is also called by the brand names Sudafed or Galpseud Linctus. Shortness of breath, a big weight gain, or swelling in the arms or legs. Under side effects "Patients with congestion and hypertension are typically advised to avoid products containing phenylephrine". Description: Triprolidine, an alkylamine derivative, is a potent competitive histamine H1-receptor antagonist hence, inhibiting the ability of histamine to combine with its receptor sites and exert its usual effects on target cells. NCI CPTC Antibody Characterization Program. Both pseudoephedrine and phenylephrine can cause side effects. Cautions. Studies with more women had less effect on BP or HR. Find everything you need to know about Ibuprofen And Pseudoephedrine (Advil Cold & Sinus), including what it is used for, warnings, reviews, side effects, and interactions. Pseudoephedrine treats sinus and nasal congestion due to the common cold or allergies. Diuretics are used to lower high blood pressure by helping the body to excrete excess water and sodium. Other beneficial effects may include increasing the drainage of sinus secretions, and opening of obstructed Eustachian tubes. Common side effects of these diuretics include nausea, headache and stomach upset. Less common are dysuria, syncope, tachycardia, palpitations, headache, nausea and vomiting, trembling, and weakness. Related Links List Loratadine-Pseudoephedrine Tablet, Extended Release side effects by likelihood and severity. The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. 3 The cardiovascular effects, subjective effects, and abuse potential of single intranasal doses of ephedrine 5 and 10 mg have been compared with oral doses of (−)ephedrine 50 mg in 16 healthy Caucasian men with no drug/alcohol/nicotine abuse or … Results of a phase III, 8-week, multicenter, prospective, randomized, double-blind, parallel-group clinical trial to assess the effects of amlodipine camsylate versus amlodipine besylate in Korean adults with mild to moderate hypertension. Hepatic. Patients with stable, controlled hypertension do not seem to be at higher risk for BP elevation than other groups when given pseudoephedrine along with their antihypertensive medications." Phenylephrine vs Pseudoephedrine – Side Effects and Uses. Chest pain or pressure. Use caution in mild to moderate hypertension, cardiac disease, hyperthyroidism, hyperglycemia, BPH, DM, renal impairment, seizure disorder, thyroid dysfunction, glaucoma, lactation. Nearly 33% of adults in the United States have the typically symptomless disease known as “hypertension.” 1 When health care providers treat ailments in these individuals, caution should be exercised, as several medications are contraindicated. 3 DISEASE INTERACTIONS Pseudoephedrine is contraindicated in patients with … Summary: Pulmonary hypertension is reported only by a few people who take Loratadine And Pseudoephedrine Sulfate.  |  Pseudoephedrine is a … Non-prescription sympathomimetic agents and hypertension. Methods: Twenty-five patients with controlled hypertension were enrolled in a randomized, placebo-controlled, double-blind crossover trial. This may often be mistaken for stress, although quite often individuals who are experiencing stress may develop hypertension… Nervous system Pseudoephedrine is excreted in breast milk in small amounts, but the effect of this on breast-fed infants is not known. NIH Pseudoephedrine caused a small but significant increase in SBP (0.99, mm Hg; 95% CI, 0.08 to 1.90) and HR (2.83 beats/min; 95% CI, 2.0 to 3.6), with no effect on DBP (0.63 mm Hg, 95% CI, -0.10 to 1.35). Background: While the effects listed above are more consistent with continued use and not generally life-threatening, some symptoms can occur when the dose is increased. The impact of oral phenylpropanolamine on blood pressure: a meta-analysis and review of the literature. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. NLM The usual dose was one tablet every 12 … Expert advice for pseudoephedrine . Mean pulse rates were 76.8 and 75.2 beats per minute in patients given pseudoephedrine and those given placebo, respectively (P = NS). Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of the effects on blood pressure of abrupt cessation versus taper down of guanfacine extended-release tablets in adults aged 19 to 24 years. Non-prescription sympathomimetic agents and hypertension. Pseudoephedrine’s propensity to raise blood pressure was the subject of a meta-analysis conducted in 2005. Phenylephrine . Reported effects include dizziness, syncopal episodes, palpitations, ventricular arrhythmias, including torsades de pointes, cardiac arrest, and cardiac death. Pseudoephedrine can … Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. J Clin Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. The purpose of this study was to determine the effects of therapeutic doses of pseudoephedrine on blood pressure in patients with controlled hypertension. Phenylephrine vs Pseudoephedrine – Side Effects and Uses. Pseudoephedrine is a popular decongestant, but products containing it are only … These include CNS stimulation, excitability, restlessness, insomnia and nervousness, tachycardia or palpitations, tremors and irritability, mania, hypertension, impotence, anginal pain, and rebound congestion. Pulmonary hypertension causes right ventricular ischemia and failure as a result of increased afterload combined with reduced coronary blood flow. Please enable it to take advantage of the complete set of features! Serious side effects of Sudafed include high blood pressure (hypertension), heart attack, abnormal heartbeats, and ischemic colitis. Herring CT, Maryansky K, Trivette K, Hemberg N. Decongestant use in hypertension. Study quality was assessed using the methods of Jadad, and data were synthesized using a random-effects model and weighted mean differences. Epub 2008 Jun 12. Within 14 days of MAO inhibitor therapy. The purpose of this study was to determine the effects of therapeutic doses of pseudoephedrine on blood pressure in patients with controlled hypertension. Less common are dysuria, syncope, tachycardia, palpitations, headache, nausea and vomiting, trembling, and weakness. Again, such side effects should send you to you physician for help. 2018 Oct 5;4(1):44. doi: 10.1186/s40798-018-0159-7. Common side effects of Sudafed include tremor, restlessness, insomnia, nausea, vomiting, and nervousness. Severe hypertension, severe CAD. eCollection 2019. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. If you experience any of the following symptoms, call your doctor immediately: nervousness; dizziness ; difficulty sleeping; stomach pain; difficulty breathing; … The authors concluded, "Pseudoephedrine modestly increases SBP and HR, with the greatest effects seen in IR formulations, higher doses, and shorter-term medication administration. The SinuSonic: reducing nasal congestion with acoustic vibration and oscillating expiratory pressure. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Although there have been no reports of hypertensive crisis, it may … The effect in patients with controlled hypertension demonstrated an SBP increase of similar magnitude (1.20 mm Hg; 95% CI, 0.56 to 1.84 mm Hg).  |  This medication is the decongestant of the mucous … Palpitations, tachycardia, arrhythmia, hypertension, reflex bradycardia, coronary occlusion, cerebral vasculitis, myocardial infarction, cardiac arrest, and death have been reported. Blood pressure and heart rate effects following a single dose of bitter orange. 2008 Dec;42(12):1766-71. doi: 10.1345/aph.1L319. Blood pressure readings were taken at the beginning and end of each week of the trial, and at a 1-week poststudy follow-up visit. It is marketed as an alternative for other types of decongestants since it reduces the size of the … Occasional use of this drug is known to induce palpitations. We assessed whether pseudoephedrine causes clinically meaningful elevations in HR or BP. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Results: Pseudoephedrine may cause side effects. Kim SH, Kim YD, Lim DS, Yoon MH, Ahn YK, On YK, Lee JW, Kim IJ, Park JB, Kim JJ, Chung WS, Yang JY, Seo HS, Shin EK, Kim HS; Korean Multicenter Amlodipine Study Investigators. Exceptions to legal category Galpseud ® and Sudafed ® can be sold to the public provided no more than 720 mg of pseudoephedrine salts are supplied, and ephedrine base (or salts) are not supplied at the same time; for details see Medicines, Ethics and Practice , London, Pharmaceutical Press (always … Cardiovascular side effects of pseudoephedrine have included significant increases in heart rate. Subjects were randomly assigned to receive pseudoephedrine or placebo during the 2nd week of the study, and to receive the opposite during the 4th week of the study. Br J Clin Pharmacol. The authors concluded, "Pseudoephedrine modestly increases SBP and HR, with the greatest effects seen in IR formulations, higher doses, and shorter-term medication administration. Other beneficial effects may include increasing the drainage of sinus secretions, and opening of obstructed Eustachian tubes. doi: 10.1371/journal.pone.0193886. Chua SS, Benrimoj SI. The decongestant helps alleviate allergy symptoms by shrinking the blood vessels to relieve nasal and sinus pressure. The cardiovascular effects, subjective effects, and abuse potential of single intranasal doses of ephedrine 5 and 10 mg have been compared with oral doses of (−)ephedrine 50 mg in 16 healthy Caucasian men with no drug/alcohol/nicotine abuse or dependence [13]. It is also used to temporarily relieve sinus congestion and pressure. Epub 2008 Nov 18. 2018 Jun 14;7(6):150. doi: 10.3390/jcm7060150. Curr Hypertens Rep. 2017 May;19(5):39. doi: 10.1007/s11906-017-0736-z. PLoS One.  |  Occasional use of this drug is known to induce palpitations. 1. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Pseudoephedrine treats sinus and nasal congestion due to the common cold or allergies. Experience from controlled and uncontrolled clinical studies involving approximately 10,000 patients who received the combination of loratadine; pseudoephedrine sulfate for a period of up to 1 month provides information on adverse reactions. USA.gov. Phenylephrine … Patients with stable, controlled hypertension do not seem to be at higher risk for BP elevation than other groups when given pseudoephedrine along with their antihypertensive medications." Hello, we provide concise yet detailed articles on "Effect Choices: Pseudoephedrine - Sudafed Side Effects" topic. 2019 Aug 28;12:305-310. doi: 10.2147/MDER.S212207. Hypertension. J Hum Hypertens. No cardiovascular effects of single-dose pseudoephedrine in patients with essential hypertension treated with beta-blockers Eur J Clin Pharmacol. Efficacy and tolerability of nebivolol monotherapy by baseline systolic blood pressure: a retrospective analysis of pooled data from two multicenter, 12-week, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging studies in patients with mild to moderate essential hypertension. To lessen the side effects of antihistamines and further reduce allergy symptoms, some allergy medicines combine an antihistamine with a decongestant, such as pseudoephedrine or phenylephrine.  |  The information here is sourced well and enriched with great visual photo and video illustrations. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2018 Mar 1;13(3):e0193886. Pseudoephedrine releases endogenous norepinephrine which … 2006 Jan;40(1):53-7. doi: 10.1345/aph.1G488. Twenty-five patients with controlled hypertension were enrolled in a randomized, placebo-controlled, double-blind crossover trial. December 2, 2020 December 2, 2020 by Your Health Remedy's Staff. Pharmacokinetics of Tedizolid and Pseudoephedrine Administered Alone or in Combination in Healthy Volunteers. … The antibacterial agent furazolidone is known to cause progressive inhibition of monoamine oxidase (a metabolite of furazolidone is a MAOI). While pseudoephedrine may be viewed as less harmful than other drugs based on its classification as an over-the-counter drug, that should not allow someone to … The effect in patients with controlled hypertension demonstrated an SBP increase of similar magnitude (1.20 mm Hg; 95% CI, 0.56 to 1.84 mm Hg). Acrivastine and pseudoephedrine combination is used to treat an itchy or runny nose, sneezing, or other symptoms caused by seasonal hay fever (allergic rhinitis). Very bad dizziness or passing out. somnolence, agitation) with atomoxetine; increased BP or heart rate with sibutramine. Clipboard, Search History, and several other advanced features are temporarily unavailable. Side effects, drug interactions, dosage, storage, and pregnancy and breastfeeding safety information is … Elderly may be more sensitive to side effects. It might also make you feel restless, nervous or shaky. As with other sympathomimetic agents, Pseudoephedrine should be used with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and … These include CNS stimulation, excitability, restlessness, insomnia and nervousness, tachycardia or palpitations, tremors and irritability, mania, hypertension, impotence, anginal pain, and rebound congestion. 1. This was a 4-week study in which all participants received placebo during the 1st and 3rd weeks. We searched MEDLINE, EMBASE, and the Cochrane Library for English-language, randomized placebo-controlled trials of oral pseudoephedrine treatment in adults. Hypertension. The use of the decongestant pseudoephedrine has been avoided in hypertensive patients with little evidence to support this caution. Use of Sudafed by pregnant women has not been adequately evaluated. Pseudoephedrine generally causes a significant rise in heart rate. Some adverse effects of pseudoephedrine that typically do not need medical attention and that may subside during use include nervousness, restlessness, and trouble sleeping. J Fam Pract . Acrivastine is an antihistamine. Drugs used to treat migraines, called ergot alkaloids, such as: ergotamine, dihydroergotamine and methylergometrine (used to stop bleeding). Histamine can cause itching, sneezing, runny nose, and watery eyes. Although Pseudoephedrine has virtually no pressor effects in normotensive patients, it should be used with caution in patients suffering mild to moderate hypertension. Conclusions: The phase IV clinical study is created by eHealthMe based on reports of 466 people who have side effects while taking Loratadine and pseudoephedrine sulfate from the FDA, and is updated regularly. Pseudoephedrine is in a class of medications called nasal decongestants. The mean diastolic pressure was 82 mm Hg in patients receiving pseudoephedrine and 82.5 mm Hg in patients receiving placebo. Some adverse effects of pseudoephedrine that typically do not need medical attention and that may subside during use include nervousness, restlessness, and trouble sleeping. Dickinson H, Campbell F, Beyer F, Nicolson Dj, Cook J, Ford G, Mason J. J Hum Hypertens. Med Toxicol Adverse Drug Exp. This site needs JavaScript to work properly. Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, Azar A, Baroody FM, Bachert C, Canonica GW, Chacko T, Cingi C, Ciprandi G, Corey J, Cox LS, Creticos PS, Custovic A, Damask C, DeConde A, DelGaudio JM, Ebert CS, Eloy JA, Flanagan CE, Fokkens WJ, Franzese C, Gosepath J, Halderman A, Hamilton RG, Hoffman HJ, Hohlfeld JM, Houser SM, Hwang PH, Incorvaia C, Jarvis D, Khalid AN, Kilpeläinen M, Kingdom TT, Krouse H, Larenas-Linnemann D, Laury AM, Lee SE, Levy JM, Luong AU, Marple BF, McCoul ED, McMains KC, Melén E, Mims JW, Moscato G, Mullol J, Nelson HS, Patadia M, Pawankar R, Pfaar O, Platt MP, Reisacher W, Rondón C, Rudmik L, Ryan M, Sastre J, Schlosser RJ, Settipane RA, Sharma HP, Sheikh A, Smith TL, Tantilipikorn P, Tversky JR, Veling MC, Wang Y, Westman M, Wickman M, Zacharek M. Int Forum Allergy Rhinol. Decongestants can make blood pressure worse in two ways: Decongestants may make your blood pressure and heart rate rise. Methods: We give advice on using this decongestant medicine (pseudoephedrine) to relieve a blocked nose, including how it works, who shouldn't use it and side effects. 2005 May;27(5):578-87. doi: 10.1016/j.clinthera.2005.05.006. Pseudoephedrine caused a small but significant increase in SBP (0.99, mm Hg; 95% CI, 0.08 to 1.90) and HR (2.83 beats/min; 95% CI, 2.0 to 3.6), with no effect on DBP (0.63 mm Hg, 95% CI, -0.10 to 1.35). Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: the VAST study. Exceptions to legal category Galpseud ® and Sudafed ® can be sold to the public provided no more than 720 mg of pseudoephedrine salts are supplied, and ephedrine base (or salts) are not supplied at the same time; for details see Medicines, Ethics and Practice , London, Pharmaceutical Press (always … 5 Investigators confirmed that it caused a small but significant increase in systolic blood pressure, but greater effects when a patient took immediate-release products or higher doses. Please enable it to take advantage of the complete set of features! Find everything you need to know about Pseudoephedrine And Triprolidine (Actifed), including what it is used for, warnings, reviews, side effects… In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Any unexplained bruising or bleeding. Chronic rhinosinusitis increases the risk of hemorrhagic and ischemic stroke: A longitudinal follow-up study using a national sample cohort. Pseudoephedrine caused a small but significant increase in SBP (0.99, mm Hg; 95% CI, 0.08 to 1.90) and HR (2.83 beats/min; 95% CI, 2.0 to 3.6), with no effect on DBP (0.63 mm Hg, 95% CI, –0.10 to 1.35). Blood pressure as an example of a biomarker that functions as a surrogate. Side effects, drug interactions, dosage, storage, and pregnancy … HHS At the onset of high blood pressure however, the first recognizable sign may be recurrent headaches. 1995 Jan;40(1):22-6. eCollection 2018. Dose-response study of the nasal decongestant and cardiovascular effects of pseudoephedrine. It is the active ingredient in many generic products, including over-the-counter (OTC) drugs and children’s cough medications. The Microbiology and Management of Acute and Chronic Rhinosinusitis. COVID-19 is an emerging, rapidly evolving situation. Another potential and disconcerting side effect of an overdose of pseudoephedrine is hallucinations 3. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Some common side effects associated with a pseudoephedrine therapy include the stimulation of the central nervous system, insomnia, excitability, anxiety, and dizziness. 1999 Jun;55(4):251-4. doi: … SIDE EFFECTS. Use caution in mild to moderate hypertension, cardiac disease, hyperthyroidism, hyperglycemia, BPH, DM, renal impairment, seizure disorder, thyroid dysfunction, glaucoma, lactation. Ann Pharmacother. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. 62.244.182.162 ( talk ) 14:10, 1 October 2008 (UTC) Find everything you need to know about Pseudoephedrine (Sudafed), including what it is used for, warnings, reviews, side effects, and interactions. Clin Ther. 2007 Sep;29(9):1924-36. doi: 10.1016/j.clinthera.2007.09.018. When you find the article helpful, feel free to share it … Often individuals suffering from hypertension may experience no symptoms at all in the early stages. Common side effects of pseudoephedrine. It directly stimulates α- and β- adrenergic receptors … Indications: This medication is used in allergic rhinitis (runny nose), vasomotor rhinitis (chronic sneezing), common cold, influenza. Pseudoephedrine: Increased adverse effects (e.g. Concomitant use of these drugs with Clarinase can cause serious side effects. Hypertension and arrhythmias have also been problematic in susceptible patients. This site needs JavaScript to work properly. Pseudoephedrine can be used either as oral or as topical decongestant. December 2, 2020 December 2, ... check with your healthcare professional before using it if you have hypertension or other heart conditions. Hypertension side effects can range from mild to severe. Surely this can't be right? Some common side effects associated with a pseudoephedrine therapy include the stimulation of the central nervous system, insomnia, excitability, anxiety, and dizziness. Med Devices (Auckl). Empey DW, Young GA, Letley E, John GC, Smith P, McDonnell KA, Bagg LR, Hughes DT. Concomitant use with these drugs can cause high blood pressure (hypertension). Hypertension and arrhythmias due to pseudoephedrine may be problematic in susceptible patients. USA.gov. Interactions [ edit ] When sympathomimetics are given to patients receiving monoamine oxidase inhibitors (MAO inhibitors), hypertensive reactions, including hypertensive crises may occur. 2007 Sep;29(9):1967-79. doi: 10.1016/j.clinthera.2007.09.020. Ann Allergy Asthma Immunol. There were no statistically significant or clinically important differences in the mean systolic or mean diastolic blood pressures among the groups during the entire 4-week course of the study. You may report side effects to Health Canada at 1-866-234-2345. Loop diuretics, thiazide diuretics and potassium sparing diuretics are all used for hypertension. Find patient medical information for Pseudoephedrine-Codeine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Relaxation therapies for the management of primary hypertension in adults: a Cochrane review. Related Links List Desloratadine-Pseudoephedrine Tablet, Extended Release Multiphase 24 Hr (Tablet, ER Hr) side effects … The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Find everything you need to know about Pseudoephedrine And Triprolidine (Actifed), including what it is used for, warnings, reviews, side effects, and interactions. Systemic administration of pseudoephedrine, up to 50 times the human daily dosage in rats and up to 35 times the human daily dosage in rabbits, did not produce teratogenic effects. Cautions. At standard doses, pseudoephedrine has no significant effect on systolic or diastolic blood pressure in patients with controlled hypertension. Lee WH, Kim JW, Lim JS, Kong IG, Choi HG. Would you like email updates of new search results? You may report side effects to Health Canada at 1-866-234-2345. See "What Are Side Effects Associated with Using Pseudoephedrine?" Long-Term Effects. Pseudoephedrine is a sympathomimetic agent which has a decongestant action on the nasal mucosa. A standard oral dose of pseudoephedrine does not significantly affect blood pressure values in hypertensive patients treated with beta-blockers, and therefore may be safely used in this subset of patients. Pseudoephedrine side effects are sympathomimetic. Severe Side Effects of Pseudoephedrine Overdose. 2006 Mar 10;8(1):E146-52. These may take the form of seeing things not really there, hearing things that others don’t hear or having physical sensations of something that does not exist touching you. Severe hypertension, severe CAD. Increasing coronary driving pressure by raising aortic pressure with phenylephrine has been shown to reverse right ventricular ischemia from pulmonary hypertension in animals. COVID-19 is an emerging, rapidly evolving situation. AAPS J. High blood pressure is found among people who take Pseudoephedrine hydrochloride, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take medication Cymbalta, and have Bipolar disorder. Studies have also found rare side effects such as hypertension, hallucinations, and seizures. See "What Are Side Effects Associated with Using Pseudoephedrine?” Cautions. Hepatic side effects of acetaminophen have included severe and sometimes fatal dose dependent hepatitis in alcoholic patients. Ruilope LM, Malacco E, Khder Y, Kandra A, Bönner G, Heintz D. Clin Ther. It works by causing narrowing of the blood vessels in the nasal passages. Clin Ther. Interactions, adverse effects and contraindications are described in more detail in the articles about pseudoephedrine and loratadine. It might also make you feel restless, nervous or shaky. 1988 Sep-Oct;3(5):387-417. doi: 10.1007/BF03259892. Gheorghiev MD, Hosseini F, Moran J, Cooper CE. Ann Pharmacother. Read "A controlled clinical trial on the cardiovascular effects of single doses of pseudoephedrine in hypertensive patients., British Journal of Clinical Pharmacology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A national sample cohort 10 ; 8 ( 1 ):53-7. doi:.. It is also called by the brand names Sudafed or Galpseud Linctus pseudoephedrine on pressure... 2008 Dec ; 42 ( 12 ):1766-71. doi: 10.1016/S1081-1206 ( 10 ).... It pseudoephedrine side effects hypertension you have hypertension or other heart conditions no cardiovascular effects of (! 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